Department of Neurology, N39
Nordre Ringvej, 57
DK-2600, Glostrup

 

glostruphospital.dk

 

Project leader

 
Prof. Jes Olesen
 
Phone +45 38 63 30 43
Fax +45 38 63 39 70
E-Mail  

Project staff

 
Ann-Louise Esserlind, MD
 
Phone +45 38 63 27 14
E-Mail  

 

 
Anne Francke Christensen, MD
Head of Biological Materials
Phone +45 38 63 43 58
E-Mail  

 

 
Anine Terese Westh Skibsted
Student
E-Mail  

 

 
Benjamin Naveed Janjooa
Student
E-Mail  

 

 
Amina Aharaz
Student
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Institute presentation

Danish Headache Center is a national center of Excellence that receives particularly rare or particularly severe cases of migraine and other headaches as well as trigeminal neuralgia. Patients come from all over Denmark and to some extent from other EU countries. There is a staff of 35 people working with the diagnosis and management of headache patients. In addition our multidisciplinary research group consists of approximately 25 full time persons. They are devoted to a range of different avenues of headache research, one of which is the genetics of headache disorders. As part of this work a group of 1250 patients with migraine without aura and 1250 patients who have migraine with aura as well as 150 patients with rare monogenic condition familial hemiplegic migraine have been phenotyped using a standardized and validated semi-structured interview. DNA from all these patients is currently being used partly exom chipping and partly in collaboration with the genetics company deCODE in Iceland as well as in collaboration with International Headache Genetics Consortium led by professor Arno Palotie, Sanger Institute Cambridge. It is from this rich clinical material that we shall select particularly suitable patients for isolation of fibroblasts. Other avenues of interest are the following: Experimental provocation of migraine using intravenous infusion of endogenous signalling molecules combined with advanced MR angiography and other MR techniques. Treatment of migraine patients and cluster headache patients with electrical stimulation, other projects in cluster headache, studies of medication overuse headache and, finally, studies of the basic mechanisms of migraine and other headaches in the rat. We do provocation with NO donors such as nitroglycerin and other endogenous signalling molecules, histochemical and biochemical studies of migraine pathways, pharmacological characterization of substances known to cause migraine in patients and finally, the development of a predictive animal model of migraine including a behavioural model. We look very much forward to use cells derived from pluripotent stem cells as we already do considerable work on cell cultures.