Department of Neurology
University of Luebeck
The Section of Clinical and Molecular Neurogenetics (Head: Prof. Christine Klein) at the Department of Neurology at the University of Luebeck focuses its clinical and research activities on hereditary forms of movement disorders, mainly Parkinson disease and dystonia. Discovering the genetic factors causing or contributing to movement disorders is the Section’s main aim of research.
With an interdisciplinary team of movement disorder specialists, clinician and basic scientists, study nurses and research technologists, PhD and medical students closely collaborating, the research is translational in nature and directed from the patient to the bench and back. Patients with genetic movement disorders undergo multimodal neuroimaging and electrophysiology studies and frequently participate in long-term follow-up or prospective clinical-genetic studies. Main research methods include molecular neurogenetics, functional analyses of proteins and molecular pathways using cellular models and, most recently, animal models. To study disease mechanisms of neurological disorders in a biologically relevant cell system, induced pluripotent stem (iPS) cells are generated by reprogramming of patient-specific skin fibroblasts. These iPS cells are differentiated into disease-linked neuronal subtypes and investigated for genetically caused phenotypes.
The Neurogenetics Section is engaged in a large network of national and international collaborations and actively participates in data and sample exchange.