StemBANCC presentations at the ISSCR 2017:

Human Stem Cells Models for Drug Discovery - Martin Graf, Veronica Costa, Christoph Patsch, Sannah Zoffmann, Mark Burcin (Hoffmann-La Roche)


Modeling FTDP-17 linked tauopathies and Alzheimer’s Disease with genetically modified human IPSC - An Verheyen (Janssen R&D)


Reproducibility of a Cellular Disease Phenotype And a Long-term Differentiation Protocol for Human iPSC-Derived Neurons - Viktor Lakics (AbbVie)


The role of Aβ in inducing an Alzheimer’s Disease specific transcriptional profile in iPSC-derived neurons - Carlo Cusulin on behalf of the team Disease Relevant Cellular Assays group (Hoffmann-La Roche)




R. Livesey et al. (2016). 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species - Specific Differences in progenitor behaviour contributing to brain size. Cell Stem Cell. 2016 Apr 7; 18(4):467-80. doi: 10.1016/j.stem.2016.03.003. Epub 2016 Mar 31.


C. Kropp et al (2016). Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors. Stem Cells Transl Med. 2016 Jul 1. doi: 10.5966/sctm.2015-0253.

B. Andree et al. (2016). Directing Cardiomyogenic Differentiation and Transdifferentiation By Ectopic Gene Expression - Direct Transition Or Reprogramming Detour? Curr Gene Ther. 2016;16(1):14-20. doi: 10.2174/1566523216666160104141522.


I. Neganova et al (2016). JNK/SAPK signalling is essential for efficient reprogramming of human fibroblasts to induced pluripotent stem cells. Stem Cells. 2016 May; 34(5):1198-212. doi: 10.1002/stem.2327. Epub 2016 Mar 4.


O. Ciampi, R. Iacone, L. Longaretti et al. (2016). Generation of functional podocytes from human induced pluripotent stem cells. Stem Cell Res. 2016 Jul; 17(1):130-9. doi: 10.1016/j.scr.2016.06.001. Epub 2016 Jun 3.


Kraushaar et al. (2016). Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection. J Pharmacol Toxicol Methods. 2016 Aug 9; 82:74-82. doi: 10.1016/j.vascn.2016.08.002. [Epub ahead of print].


S. Efrat (2016). Mechanisms of adult human β-cell in-vitro dedifferentiation and redifferentiation. Diabetes Obes Metab. 2016 Sep; 18 Suppl 1:97-101.doi: 10.1111/dom.12724.


O. Friedman-Mazursky et al. (2016). Redifferentiation of human islet β cells expanded in vitro by inhibition of ARX. Scientific Reports 2016 Feb 9;6:20698. doi: 10.1038/srep20698.


I. Kopljar, D.J. Gallacher et al. (2016). Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells Transl Med. 2016 May;5(5):602-12. doi: 10.5966/sctm.2015-0279. Epub 2016 Mar 31.


F. Knöspel, F. Jacobs, N. Freyer et al. (2016). In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System. Int. J. Mol. Sci. 2016, 17, 584. doi:10.3390/ijms17040584.


Freyer N, Knöspel F, Strahl N, et al. (2016). Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor. BioResearch Open Access. 2016;5(1):235-248. doi:10.1089/biores.2016.0027.


J. Christoffersson  et al. (2016). A microfluidic bioreactor for toxicity testing of stem cell derived 3D cardiac bodies. Methods Mol Biol. 2016;1502:159-68. doi: 10.1007/7651_2016_340.


N. Beer et al (2016). Genome edited human stem cell-derived beta-cells: a powerful tool for drilling down on type 2 diabetes GWAS biology. F1000Res. 2016 Jul 15;5. pii: F1000 Faculty Rev-1711. doi: 10.12688/f1000research.8682.1. eCollection 2016.


N. Beer et al (2016). Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model. Islets. 2016 Apr 18;8(3):83-95. doi: 10.1080/19382014.2016.1182276.


A. E. Handel et al. (2016). Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics. Hum Mol Genet. 2016 Mar 1;25(5):989-1000. doi: 10.1093/hmg/ddv637. Epub 2016 Jan 5.


H. J. Fernandes et al. (2016). ER stress and autophagic perturbations lead to elevated extracellular α-Synuclein in GBA-N370S parkinson's iPSC-derived dopamine neurons. Stem Cell Reports. 2016 Mar 8;6(3):342-56. doi: 10.1016/j.stemcr.2016.01.013. Epub 2016 Feb 18.


Morrison M, Briceño Moraia L, Steele J C (2016) Traceability in stem cell research: from participant sample to induced pluripotent stem cell and back, Regenerative Medicine, DOI 10.2217/rme.15.66


M. Lako et al. (2015). Inhibition of miR-145 Enhances Reprogramming of Human Dermal Fibroblasts to Induced Pluripotent Stem Cells. Stem Cells. 2016 Jan; 34(1):246-51. doi: 10.1002/stem.2220. Epub 2015 Oct 9.


H. Kempf et al. (2015). Cardiac differentiation of human pluripotent stem cells in scalable suspension culture. Nature Protocols 2015 Sep; 10(9):1345-61.doi: 10.1038/nprot.2015.089. Epub 2015 Aug 13.


H. Kempg et al. (2015). Large-scale production of human pluripotent stem cell derived cardiomyocytes. Adv Drug Deliv Rev. Review. 2016 Jan 15; 96:18-30. doi: 10.1016/j.addr.2015.11.016.


Verheyen A, Diels A, Dijkmans J,  Oyelami T, Memeghello G, Mertens L, Versweyveld S, Borgers M, Buist A, Peeters P, Cik M (2015) Using Human iPSC-Derived Neurons to Model TAU Aggregation DOI: 10.1371/journal.pone.0146127


Datta, Sagnik; Gayraud, Ghislaine; Leclerc, Eric; Bois, Frederic Y. (2015) Graph sampler: a C language software for fully Bayesian analyses of Bayesian networks. eprint arXiv:1505.07228


Nathan G, Kredo-Russo S, Geiger T, Lenz A, Kaspi H, Hornstein E, Efrat S (2015) MiR-375 promotes redifferentiation of adult human β cells expanded in vitro. PLoS One. 2015 Apr 13;10(4):e0122108. doi: 10.1371/journal.pone.0122108.


Bergström G, Christoffersson J, Schwanke K, Zweigerdt R, Mandenius CF (2015) Stem cell derived in vivo-like human cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging. Lab Chip. 2015 Jul 14;15(15):3242-9. doi: 10.1039/c5lc00449g.


Dodsworth BT, Flynn R, Cowley SA (2015) The Current State of Naïve Human Pluripotency. Stem Cells. 2015 Jun 29. doi: 10.1002/stem.2085.


Flynn R, Grundmann A, Renz P, Haenseler W, James WS, Cowley SA, Moore MD (2015) CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells. Exp Hematol. 2015 Jun 19. pii: S0301-472X(15)00207-6. doi: 10.1016/j.exphem.2015.06.002.


Patsch, C. et al. (2015) Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug;17(8):994-1003. doi: 10.1038/ncb3205. Epub 2015 Jul 27.


Bois, Frederic Y., and Ghislaine Gayraud. (2015) Probabilistic Generation of Random Networks Taking into Account Information on Motifs Occurrence. Journal of Computational Biology 22 (2015): 25–36. doi:10.1089/cmb.2014.0175


Morrison M, Klein C, Clemann N, Collier DA, Hardy J, Heisserer B, Cader ZM, Graf M, Kaye J (2015) StemBANCC: Governing Access to Material and Data in a Large Stem Cell Research Consortium. Stem Cell Reviews and Reports


Davies, JA, Chang CH. (2014) Engineering kidneys from simple cell suspensions: an exercise in self-organization. Pediatr Nephrol. 2014 Apr;29(4):519-24. doi: 10.1007/s00467-013-2579-4.


Davies JA (2014) Engineered renal tissue as a potential platform for pharmacokinetic and nephrotoxicity testing. Drug Discov Today. 2014 Jun;19(6):725-9. doi: 10.1016/j.drudis.2013.10.023.


Davies JA, Chang C-H, Lawrence ML, Mills CG, Mullins JJ (2014) Engineered kidneys: principles, progress and prospects. Advances in Regenerative Biology 2014, 1: 24990. doi:10.3402/arb.v1.24990.


Wilmes A, Aschauer L, Limonciel A, Pfaller W, Jennings P. (2014) Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72. doi: 10.1016/j.taap.2014.05.013.


Soggia A, Ramond C, Akiyama H, Scharfmann R, Duvillie B. (2014) Von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-alpha and VEGF-A up-regulation. Diabetologia. 2014 Nov;57(11):2348-56. doi: 10.1007/s00125-014-3365-y.


Rachdi L, Kariyawasam D, Aïello V, Herault Y, Janel N, Delabar JM, Polak M, Scharfmann R. (2014) Dyrk1A induces pancreatic beta cell mass expansion and improves glucose tolerance. Cell Cycle. 2014 Jul 15;13(14):2221-9. doi: 10.4161/cc.29250.


Bois FY, Gayraud G. (2014) Probabilistic generation of random networks taking into account information on motifs occurrence. Journal of Computational Biology. January 2015, 22(1): 25-36. doi:10.1089/cmb.2014.0175.


Rachdi L, Kariyawasam D, Aïello V, Herault Y, Janel N, Delabar JM, Polak M, Scharfmann R. (2014) Dyrk1a haploinsufficiency induces diabetes through decreased pancreatic beta cell mass. Diabetologia. 2014 May;57(5):960-9. doi: 10.1007/s00125-014-3174-3.


Hoarau E, Chandra V, Rustin P, Scharfmann R, Duvillie B. (2014) Pro-Oxidant/Anti-Oxidant balance controls pancreatic ß-cell differentiation through the ERK1/2 pathway. Cell Death Dis 2014 23;5:e1487


Kempf H, Olmer R, Kropp C, Rückert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R. (2014) Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture. Stem Cell Reports. 2014 Dec 9;3(6):1132-46.


Zweigert, R. & Graf, M. (2013) "StemBANCC: iPSC-basierte Zell- und Tox-Modelle" in Laborwelt, 3/2013


Honore C & Hansson M. (2013) "Disease modeling and drug discovery using human pluripotent stem cells." in Stem Cell: Current Challenges and New Directions.Stem Cell Biology and Regenerative Medicine. pp317-340.


Nissenbaum J, Bar-Nur O, Ben-David E, Benvenisty N (2013) Global Indiscriminate Methylation in Cell-Specific Gene Promoters following Reprogramming into Human Induced Pluripotent Stem Cells. StemCellReports, Vol. 1, 509–517, Dec 17, 2013.