StemBANCC presentations at the ISSCR 2017:


Human Stem Cells Models for Drug Discovery - Martin Graf, Veronica Costa, Christoph Patsch, Sannah Zoffmann, Mark Burcin (Hoffmann-La Roche)

 

Modeling FTDP-17 linked tauopathies and Alzheimer’s Disease with genetically modified human IPSC - An Verheyen (Janssen R&D)

 

Reproducibility of a Cellular Disease Phenotype And a Long-term Differentiation Protocol for Human iPSC-Derived Neurons - Viktor Lakics (AbbVie)

 

The role of Aβ in inducing an Alzheimer’s Disease specific transcriptional profile in iPSC-derived neurons - Carlo Cusulin on behalf of the team Disease Relevant Cellular Assays group (Hoffmann-La Roche)

 

Publications:

 

Datta S. et al. (2017). Graph_sampler: a simple tool for fully Bayesian analyses of DAG-models. Computational Statistics. June 2017, Volume 32, Issue 2, pp 691–716. https://doi.org/10.1007/s00180-017-0719-1

 

Honore C. et al. (2017). Revisiting the immunocytochemical detection of Neurogenin 3 expression in mouse and man. Diabetes Obes Metab. 2016 Sep;18 Suppl 1:10-22. doi: 10.1111/dom.12718.

 

Wassmer T. et al. (2017). Extracellular monomeric and aggregated tau efficiently enter human neurons through overlapping but distinct pathways. biorxiv. doi: https://doi.org/10.1101/168294

 

Christoffersson J. et al. (2017). Developing organ-on-a-chip concepts using bio-mechatronic design methodology. Biofabrication. 2017 May 26;9(2):025023. doi: 10.1088/1758-5090/aa71ca.

 

Thurner M. et al. (2017). Genes associated with pancreas development and function maintain open chromatin structure in iPSCs generated from human pancreatic beta cells. Stem Cell Reports. DOI: http://dx.doi.org/10.1016/j.stemcr.2017.09.020.

 

Massai D. et al. (2017). Sensitivity of human pluripotent stem cells to insulin precipitation induced by peristaltic pump-based medium circulation: considerations on process development. Scientific Reports 7, Article number: 3950 (2017). doi:10.1038/s41598-017-04158-x

 

Weber N. et al. (2017). Stiff matrix induces switch to pure b-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes. Basic Res Cardiol. 2016 Nov;111(6):68. Epub 2016 Oct 14.

 

Kempf H. et al. (2017). Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nature Communications 7, Article number: 13602 (2016). doi:10.1038/ncomms13602

 

Jara-Avaca M. et al. (2017). EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival. Stem Cell Reports. Volume 8, Issue 2, p305–317, 14 February 2017. DOI: http://dx.doi.org/10.1016/j.stemcr.2016.12.012

 

Bownjohn P. W. (2017). Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease. Stem Cell Reports. Volume 8, Issue 4, p870–882, 11 April 2017. DOI: http://dx.doi.org/10.1016/j.stemcr.2017.02.006

 

Wilmes A. et al. (2017). Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion. Toxicol In Vitro. 2017 Aug 15. pii: S0887-2333(17)30209-6. doi: 10.1016/j.tiv.2017.07.023. [Epub ahead of print]

 

Meier F. et al (2017). Hepatic Differentiation of Human iPSCs 2 in Different 3D Models. Int J Mol Med. 2017 Oct 16. doi: 10.3892/ijmm.2017.3190. [Epub ahead of print]

 

Zanon A. et al (2017). SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Hum Mol Genet. 2017 Jul 1;26(13):2412-2425. doi: 10.1093/hmg/ddx132.

 

Freyer N. et al. (2017). Hepatic differentiation of human induced pluripotent stem cells in a perfused three-dimensional multicompartment bioreactor. Biores Open Access. 2016 Aug 1;5(1):235-48. doi: 10.1089/biores.2016.0027. eCollection 2016.

 

Meier F. et al (2017). Hepatic differentiation of human iPSC in different 3D models: A comparative study. International Journal of Molecular Medicine. DOI: 10.3892/ijmm.2017.3190

 

Palakkan A.A. et al. (2017). Pluripotent stem cells to hepatocytes, the journey so far. Biomed Rep. 2017 Apr;6(4):367-373. doi: 10.3892/br.2017.867. Epub 2017 Mar 1.

 

Goldring C. (2017). Stem cell-derived models to improve mechanistic understanding and prediction of human drug induced liver injury. Hepatology. 2017 Feb;65(2):710-721. doi: 10.1002/hep.28886. Epub 2016 Nov 30.

 

Baud a. et al. (2017). Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells. Anal Chem. 2017 Feb 21;89(4):2440-2448. doi: 10.1021/acs.analchem.6b04368. Epub 2017 Feb 6.

 

Robbins JP, Price J (2017). Human induced pluripotent stem cells as a research tool in Alzheimer's disease. Psychol Med. 2017 Nov;47(15):2587-2592. doi: 10.1017/S0033291717002124. Epub 2017 Aug 14.

 

Kathuria A. et al (2017). Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development. Mol Psychiatry. 2017 Sep 26. doi: 10.1038/mp.2017.185. [Epub ahead of print]

 

Powell T.R. et al. (2017). Transcriptomic profiling of human hippocampal progenitor cells treated with antidepressants and its application in drug repositioning. J Psychopharmacol. 2017 Mar;31(3):338-345. doi: 10.1177/0269881117691467. Epub 2017 Feb 16.

 

Morrison M. (2017). Infrastructural expectations: Exploring the promise of international large-scale pluripotent stem cell banks. New Genetics and Society. Pages 66-83. Received 02 Nov 2016, Accepted 26 Jan 2017, Published online: 15 Feb 2017

 

Morrison M. (2017). A good collaboration is based on unique contributions from each side: assessing the dynamics of collaboration in stem cell science. Life Sci Soc Policy. 2017 Dec;13(1):7. doi: 10.1186/s40504-017-0053-y. Epub 2017 May 4.

 

Morrison M. et al. (2017). The European General Data Protection Regulation: Challenges and Considerations for iPSC Researchers and Biobanks. Regen Med. 2017 Sep;12(6):693-703. doi: 10.2217/rme-2017-0068. Epub 2017 Oct 4.

 

Sipp D. et al. (2017). Marketing of unproven stem cell-based interventions: A call to action. Sci Transl Med. 2017 Jul 5;9(397). pii: eaag0426. doi: 10.1126/scitranslmed.aag0426.

 

Beevers J. E. et al. (2017). MAPT genetic variation and neuronal maturity alter isoform expression affecting axonal transport in iPSC-derived dopamine neurons. Stem Cell Reports. Volume 9, Issue 2, p587–599, 8 August 2017. DOI: http://dx.doi.org/10.1016/j.stemcr.2017.06.005

 

Sandor C. et al. (2017). Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for parkinson's disease. Hum Mol Genet. 2017 Feb 1;26(3):552-566. doi: 10.1093/hmg/ddw412.

 

Baud A. et al. (2017). Multiplex High-Throughput targeted proteomic assay to identify induced pluripotent stem cells. Anal Chem. 2017 Feb 21;89(4):2440-2448. doi: 10.1021/acs.analchem.6b04368. Epub 2017 Feb 6.

 

Lee H. et al. (2017). LRRK2 in peripheral and central nervous system innate immunity: its link to parkinson's disease. Biochem Soc Trans. 2017 Feb 8;45(1):131-139. doi: 10.1042/BST20160262.

 

Haenseler W. et al. (2017). A highly efficient human pluripotent stem cell microglia model displays a Neuronal-Co-culture-Specific expression profile and inflammatory response. Stem Cell Reports. 2017 Jun 6;8(6):1727-1742. doi: 10.1016/j.stemcr.2017.05.017.

 

Haenseler W. et al. (2017). Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages. Scientific Reports 7, Article number: 9003 (2017). doi:10.1038/s41598-017-09362-3

 

Clark A.J. et al. (2017). Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination. Brain, Volume 140, Issue 4, 1 April 2017, Pages 898–913, https://doi.org/10.1093/brain/awx012

 

Kuijlaars J. et al. (2016). Sustained synchronized neuronal network activity in a human astrocyte co-culture system. Scientific Reports 6, Article number: 36529 (2016). doi:10.1038/srep36529

 

Kraushaar U. et al. (2016). Addressing functional neurotoxicity using the microelectrode array (MEA). Springer. Stem Cell-Derived Models in Toxicology. pp 293-309.

 

Zhu L. et al (2016). The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages. J Cell Biol. 2016 Oct 24;215(2):187-202. Epub 2016 Oct 17. DOI: 10.1083/jcb.201601061

 

R. Livesey et al. (2016). 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species - Specific Differences in progenitor behaviour contributing to brain size. Cell Stem Cell. 2016 Apr 7; 18(4):467-80. doi: 10.1016/j.stem.2016.03.003. Epub 2016 Mar 31.

 

C. Kropp et al (2016). Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors. Stem Cells Transl Med. 2016 Jul 1. doi: 10.5966/sctm.2015-0253.

B. Andree et al. (2016). Directing Cardiomyogenic Differentiation and Transdifferentiation By Ectopic Gene Expression - Direct Transition Or Reprogramming Detour? Curr Gene Ther. 2016;16(1):14-20. doi: 10.2174/1566523216666160104141522.

 

I. Neganova et al (2016). JNK/SAPK signalling is essential for efficient reprogramming of human fibroblasts to induced pluripotent stem cells. Stem Cells. 2016 May; 34(5):1198-212. doi: 10.1002/stem.2327. Epub 2016 Mar 4.

 

O. Ciampi, R. Iacone, L. Longaretti et al. (2016). Generation of functional podocytes from human induced pluripotent stem cells. Stem Cell Res. 2016 Jul; 17(1):130-9. doi: 10.1016/j.scr.2016.06.001. Epub 2016 Jun 3.

 

Kraushaar et al. (2016). Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection. J Pharmacol Toxicol Methods. 2016 Aug 9; 82:74-82. doi: 10.1016/j.vascn.2016.08.002. [Epub ahead of print].

 

S. Efrat (2016). Mechanisms of adult human β-cell in-vitro dedifferentiation and redifferentiation. Diabetes Obes Metab. 2016 Sep; 18 Suppl 1:97-101.doi: 10.1111/dom.12724.

 

O. Friedman-Mazursky et al. (2016). Redifferentiation of human islet β cells expanded in vitro by inhibition of ARX. Scientific Reports 2016 Feb 9;6:20698. doi: 10.1038/srep20698.

 

I. Kopljar, D.J. Gallacher et al. (2016). Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells Transl Med. 2016 May;5(5):602-12. doi: 10.5966/sctm.2015-0279. Epub 2016 Mar 31.

 

F. Knöspel, F. Jacobs, N. Freyer et al. (2016). In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System. Int. J. Mol. Sci. 2016, 17, 584. doi:10.3390/ijms17040584.

 

Freyer N, Knöspel F, Strahl N, et al. (2016). Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor. BioResearch Open Access. 2016;5(1):235-248. doi:10.1089/biores.2016.0027.

 

J. Christoffersson  et al. (2016). A microfluidic bioreactor for toxicity testing of stem cell derived 3D cardiac bodies. Methods Mol Biol. 2016;1502:159-68. doi: 10.1007/7651_2016_340.

 

N. Beer et al (2016). Genome edited human stem cell-derived beta-cells: a powerful tool for drilling down on type 2 diabetes GWAS biology. F1000Res. 2016 Jul 15;5. pii: F1000 Faculty Rev-1711. doi: 10.12688/f1000research.8682.1. eCollection 2016.

 

N. Beer et al (2016). Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model. Islets. 2016 Apr 18;8(3):83-95. doi: 10.1080/19382014.2016.1182276.

 

A. E. Handel et al. (2016). Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics. Hum Mol Genet. 2016 Mar 1;25(5):989-1000. doi: 10.1093/hmg/ddv637. Epub 2016 Jan 5.

 

H. J. Fernandes et al. (2016). ER stress and autophagic perturbations lead to elevated extracellular α-Synuclein in GBA-N370S parkinson's iPSC-derived dopamine neurons. Stem Cell Reports. 2016 Mar 8;6(3):342-56. doi: 10.1016/j.stemcr.2016.01.013. Epub 2016 Feb 18.

 

Morrison M, Briceño Moraia L, Steele J C (2016) Traceability in stem cell research: from participant sample to induced pluripotent stem cell and back, Regenerative Medicine, DOI 10.2217/rme.15.66

 

M. Lako et al. (2015). Inhibition of miR-145 Enhances Reprogramming of Human Dermal Fibroblasts to Induced Pluripotent Stem Cells. Stem Cells. 2016 Jan; 34(1):246-51. doi: 10.1002/stem.2220. Epub 2015 Oct 9.

 

H. Kempf et al. (2015). Cardiac differentiation of human pluripotent stem cells in scalable suspension culture. Nature Protocols 2015 Sep; 10(9):1345-61.doi: 10.1038/nprot.2015.089. Epub 2015 Aug 13.

 

H. Kempg et al. (2015). Large-scale production of human pluripotent stem cell derived cardiomyocytes. Adv Drug Deliv Rev. Review. 2016 Jan 15; 96:18-30. doi: 10.1016/j.addr.2015.11.016.

 

Verheyen A, Diels A, Dijkmans J,  Oyelami T, Memeghello G, Mertens L, Versweyveld S, Borgers M, Buist A, Peeters P, Cik M (2015) Using Human iPSC-Derived Neurons to Model TAU Aggregation DOI: 10.1371/journal.pone.0146127

 

Datta, Sagnik; Gayraud, Ghislaine; Leclerc, Eric; Bois, Frederic Y. (2015) Graph sampler: a C language software for fully Bayesian analyses of Bayesian networks. eprint arXiv:1505.07228

 

Nathan G, Kredo-Russo S, Geiger T, Lenz A, Kaspi H, Hornstein E, Efrat S (2015) MiR-375 promotes redifferentiation of adult human β cells expanded in vitro. PLoS One. 2015 Apr 13;10(4):e0122108. doi: 10.1371/journal.pone.0122108.

 

Bergström G, Christoffersson J, Schwanke K, Zweigerdt R, Mandenius CF (2015) Stem cell derived in vivo-like human cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging. Lab Chip. 2015 Jul 14;15(15):3242-9. doi: 10.1039/c5lc00449g.

 

Dodsworth BT, Flynn R, Cowley SA (2015) The Current State of Naïve Human Pluripotency. Stem Cells. 2015 Jun 29. doi: 10.1002/stem.2085.

 

Flynn R, Grundmann A, Renz P, Haenseler W, James WS, Cowley SA, Moore MD (2015) CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells. Exp Hematol. 2015 Jun 19. pii: S0301-472X(15)00207-6. doi: 10.1016/j.exphem.2015.06.002.

 

Patsch, C. et al. (2015) Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug;17(8):994-1003. doi: 10.1038/ncb3205. Epub 2015 Jul 27.

 

Bois, Frederic Y., and Ghislaine Gayraud. (2015) Probabilistic Generation of Random Networks Taking into Account Information on Motifs Occurrence. Journal of Computational Biology 22 (2015): 25–36. doi:10.1089/cmb.2014.0175

 

Morrison M, Klein C, Clemann N, Collier DA, Hardy J, Heisserer B, Cader ZM, Graf M, Kaye J (2015) StemBANCC: Governing Access to Material and Data in a Large Stem Cell Research Consortium. Stem Cell Reviews and Reports

 

Davies, JA, Chang CH. (2014) Engineering kidneys from simple cell suspensions: an exercise in self-organization. Pediatr Nephrol. 2014 Apr;29(4):519-24. doi: 10.1007/s00467-013-2579-4.

 

Davies JA (2014) Engineered renal tissue as a potential platform for pharmacokinetic and nephrotoxicity testing. Drug Discov Today. 2014 Jun;19(6):725-9. doi: 10.1016/j.drudis.2013.10.023.

 

Davies JA, Chang C-H, Lawrence ML, Mills CG, Mullins JJ (2014) Engineered kidneys: principles, progress and prospects. Advances in Regenerative Biology 2014, 1: 24990. doi:10.3402/arb.v1.24990.

 

Wilmes A, Aschauer L, Limonciel A, Pfaller W, Jennings P. (2014) Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72. doi: 10.1016/j.taap.2014.05.013.

 

Soggia A, Ramond C, Akiyama H, Scharfmann R, Duvillie B. (2014) Von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-alpha and VEGF-A up-regulation. Diabetologia. 2014 Nov;57(11):2348-56. doi: 10.1007/s00125-014-3365-y.

 

Rachdi L, Kariyawasam D, Aïello V, Herault Y, Janel N, Delabar JM, Polak M, Scharfmann R. (2014) Dyrk1A induces pancreatic beta cell mass expansion and improves glucose tolerance. Cell Cycle. 2014 Jul 15;13(14):2221-9. doi: 10.4161/cc.29250.

 

Bois FY, Gayraud G. (2014) Probabilistic generation of random networks taking into account information on motifs occurrence. Journal of Computational Biology. January 2015, 22(1): 25-36. doi:10.1089/cmb.2014.0175.

 

Rachdi L, Kariyawasam D, Aïello V, Herault Y, Janel N, Delabar JM, Polak M, Scharfmann R. (2014) Dyrk1a haploinsufficiency induces diabetes through decreased pancreatic beta cell mass. Diabetologia. 2014 May;57(5):960-9. doi: 10.1007/s00125-014-3174-3.

 

Hoarau E, Chandra V, Rustin P, Scharfmann R, Duvillie B. (2014) Pro-Oxidant/Anti-Oxidant balance controls pancreatic ß-cell differentiation through the ERK1/2 pathway. Cell Death Dis 2014 23;5:e1487

 

Kempf H, Olmer R, Kropp C, Rückert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R. (2014) Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture. Stem Cell Reports. 2014 Dec 9;3(6):1132-46.

 

Zweigert, R. & Graf, M. (2013) "StemBANCC: iPSC-basierte Zell- und Tox-Modelle" in Laborwelt, 3/2013

 

Honore C & Hansson M. (2013) "Disease modeling and drug discovery using human pluripotent stem cells." in Stem Cell: Current Challenges and New Directions.Stem Cell Biology and Regenerative Medicine. pp317-340.

 

Nissenbaum J, Bar-Nur O, Ben-David E, Benvenisty N (2013) Global Indiscriminate Methylation in Cell-Specific Gene Promoters following Reprogramming into Human Induced Pluripotent Stem Cells. StemCellReports, Vol. 1, 509–517, Dec 17, 2013.